Medically reviewed by: Dr. Chang Kempson, M.D., M.S. Expert in addiction medicine and toxicology. Can Xanax Withdrawal Kill You? Quick Answer Yes, Xanax (alprazolam) withdrawal can be life-threatening in some cases. Stopping Xanax suddenly—especially after long-term or high-dose use—can lead to serious complications such as seizures, severe anxiety, psychosis, and, in rare cases, death if left […]